Before last year's Covid-affected season, F1 had last visited Portugal in 1996 but after races in both Australia and China were postponed, the sport announced Portimão would once again feature this year.
The race proved popular last year with the undulating circuit providing a rollercoaster ride for drivers.
Hamilton stood on the top step of the podium last year to take his 92nd career victory and break the record previously held by Michael Schumacher.
This time around, Hamilton will face stiff competition from Max Verstappen. The drivers have one win each this season with the Mercedes driver topping the standings by just one point after setting the fastest lap at Imola.
In the midfield, McLaren and Ferrari have set the early pace but AlphaTauri, Aston Martin and Alpine will all be looking to strike back and prevent the points gap from widening further.
WHEN IS THE PORTUGUESE GRAND PRIX?
Practice One: 11:30 local time (11:30BST, 06:30 EDT)
Practice Two: 15:00 local time (15:00BST, 10:00 EDT)
Practice Three: 12:00 local time (12:00BST, 07:00 EDT)
Qualifying: 15:00 local time (15:00BST, 10:00 EDT)
Grand Prix: 15:00 local time (15:00BST, 10:00 EDT)
HOW CAN I WATCH THE PORTUGUESE GP IN THE UK?
Every session of the weekend will be shown live on Sky Sports' dedicated F1 channel. Customers who subscribe to Sky Sports F1 can also watch all the action on the move thanks to the Sky Go app.
Alternatively, you can purchase a NOW TV Day Pass for just £9.99 to watch all of Sky Sports' coverage on your smart TV, mobile device, tablet or computer.
IS THE PORTUGUESE GP ON CHANNEL 4?
No. Only the British Grand Prix is being shown in full on free-to-air television in the UK this year. Highlights of all other races will be shown in a 'prime-time' slot on C4.
HOW CAN I WATCH THE PORTUGUESE GP IN THE USA?
ESPN will carry live coverage of every session from Imola to subscribing fans Stateside.
Friday practice sessions will be available on ESPNU whilst all the action from Saturday and Sunday will be broadcast on ESPN2.
Live streaming is available via the ESPN App.
HOW CAN I WATCH THE PORTUGUESE GP IN AUSTRALIA?
All sessions from each weekend of the year will be broadcast live on subscription service Fox Sports or through its Kayo streaming service.
Channel 10 offers a free alternative, showing highlights of all 23 races as well as the Australian Grand Prix live. This can also be accessed by using the 10Play app.
HOW CAN I WATCH THE PORTUGUESE GP IN CANADA?
Qualifying and the race will be aired live in English on subscription channel TSN, which pulls in coverage from Sky Sports in the UK. The TSN GO app allows fans in Canada to watch F1 on the move.
French-language coverage is available on RDS to subscribers, which will air qualifying and the race live. You can download RDS GO if you are out and about.
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