Both qualifying and the race also ran past midnight and into the early hours of the morning.
The teams were still tasked with packing everything up in preparation for the final round of the season in Abu Dhabi, giving them little time to rest.
Red Bull team principal Horner had his say on the gruelling schedule.
"It's been a big event and, like in anything, there'll be a bit of a debrief to go through what was good and what needs a bit of polishing," Horner said.
"When you look at the interest there has been in this race, it has been phenomenal. As a first event, of course, there are going to be many lessons to learn.
"I think one of the things we look at is the running schedule because it's been brutal for the team, and all the men and women behind the scenes. I think everybody's leaving Vegas slightly f***ed."
Horner also spoke about the possibility of making amendments to the future schedule in order to better suit both the teams and the global television audiences.
"We need to look at how we can improve that for the future. We're running so late at night, so maybe we run it a little earlier in the evening," he added.
"You're never going to keep every television audience totally happy. This is an American race, so if you run at eight o'clock in the evening, or something like that, it would just be a bit more comfortable for all."
GPFans is a multi-platform, multi-language brand dedicated to Formula One coverage. We bring you all the ins and outs of the sport, 24/7, everything from up-to-the-minute news and features to the latest viral stories and clips.
We believe that a new generation of exciting, outspoken drivers will make F1 more popular than ever before, and we want to give our users access to as much of their heroes as possible, on and off the track. From Lewis Hamilton to Max Verstappen, Daniel Ricciardo to Sebastian Vettel, we provide in-depth analysis of every every Grand Prix in the season, from Australia to Abu Dhabi.
With Formula One under the new ownership of Liberty Media, how the sport is being covered is evolving, and GPFans will look to be at the heart of this progression into new media, as one of the fastest-growing sites covering the king of motorsports.