Leclerc knocked his front wing off in the crash which caused an early red flag, but the Monegasque driver came into the pits, changed his front wing and carried on, whilst Stroll was not so lucky.
The Aston Martin driver suffered a lot of damage to the back of his machinery, with Sky Sports F1's Ted Kravitz revealing the extent of the damage live on air: "That’s session over for Lance Stroll, there’s too much to change," he said.
"The gearbox needs changing and as well as the diffuser the door and the rear suspension as well."
Stroll's nightmare start as Newey makes trackside debut
Karun Chandhok also stated during Sky Sports' coverage of the session that the incident was '100 per cent' the fault of Stroll and his team.
It meant the Canadian missed almost an entire session of practice around the circuit which is notoriously difficult to navigate.
Drivers purposefully try to get in as many laps as possible around the circuit during the three practice sessions to work out where they can take risks as the barriers seem to close in throughout the course of each lap.
In this case, Stroll will be significantly impacted by the incident, as the weekend progresses into Saturday ahead of what could be considered the most vital qualifying of the campaign.
The 26-year-old could not have picked a worse weekend to be involved in a session-ending collision as his team welcomed F1 design guru Adrian Newey in his first appearance trackside with Aston Martin since making the shock switch from Red Bull.
Following Friday's incident, both Stroll and Leclerc were summoned to the stewards with the FIA announcing a one-place grid penalty for the Aston Martin star at Sunday's grand prix.