The incidents cost Bottas a guaranteed runner-up spot and Sainz fifth place, while Hamilton limped over the line to claim victory by just under six seconds from Red Bull's Max Verstappen after his problem sparked panic halfway into his final lap.
Pirelli boss Mario Isola has confirmed an investigation has already started at the Italian manufacturer's on-site laboratories, and if necessary will continue at their headquarters in Milan.
Assessing the possible outcomes, Isola said: "It could be high wear because tyres with 38 laps or more on this circuit are quite worn.
"It could be debris because we had the pieces of the front wing of Kimi [Raikkonen] that were on track, but also some other debris.
"So that's why we want to investigate not only the tyres with a failure, but all the tyres used in the last few laps of the race to understand if we find any other cut or possible indication on what happened.
"We have the possibility to do some analysis at our laboratories here on track. It is clear we don't have a lot of time to carry out an investigation because we have another race in less than one week, so we have to come to a conclusion as soon as possible.
"If the issue is wear then we have to think about a solution. If it was due to a puncture then obviously there is very little we can do. If there are other issues then we have to understand what they are and react in the proper way
"We don't want to exclude anything, we want to analyse everything 360 degrees and avoid excluding any possibility because it's a big mistake when you have this kind of investigation."
Isola is hoping to have answers either on Monday or Tuesday at the latest should the investigation require further analysis in Milan.
Is it possible Mercedes May have been more susceptible to tire failure because they used the DAS system when they came out after the safety car ? It changes the toe angle in order to create extra heat in the tires. Maybe that little bit of extra wear pushed their tires over the edge.
GPFans is a multi-platform, multi-language brand dedicated to Formula One coverage. We bring you all the ins and outs of the sport, 24/7, everything from up-to-the-minute news and features to the latest viral stories and clips.
We believe that a new generation of exciting, outspoken drivers will make F1 more popular than ever before, and we want to give our users access to as much of their heroes as possible, on and off the track. From Lewis Hamilton to Max Verstappen, Daniel Ricciardo to Sebastian Vettel, we provide in-depth analysis of every every Grand Prix in the season, from Australia to Abu Dhabi.
With Formula One under the new ownership of Liberty Media, how the sport is being covered is evolving, and GPFans will look to be at the heart of this progression into new media, as one of the fastest-growing sites covering the king of motorsports.